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Vol. 10, Special Issue 12 (2021)

Olive oil ameliorates the serum biochemical and haematological changes induced by cypermethrin

Author(s):
Md. Rubina, D Madhuri, B Ramya and B Kalakumar
Abstract:
The use of synthetic pyrethroids like cypermethrin has been on a rise in agriculture and other areas of pest control. Though moderately safer than other classes of pesticides pyrethroids are toxic to living beings. Recent studies reveal oxidative stress as the causative factor of the adverse effects by many pesticides. Hence olive oil, a well known antioxidant was chosen in the study to counter act the effect of cypermethrin. Twenty four adult female Wistar rats were taken and made into four groups namely control, CYP, OO and CYP+OO. CYP group rats were administered CYP @ 25mg/kg b.wt., OO group rats were administered OO @ 6g/kg b.wt and CYP+OO group rats were administered CYP @ 25mg/kg b.wt and OO @ 6g/kg b.wt. daily for 28 days. Animals were sacrificed on the 28th day of experiment and blood was collected for analysis. Significantly lower values of total erythrocyte count (TEC) and haemoglobin (Hb) were recorded in CYP group in comparison to control, OO and CYP+OO groups. Packed cell volume (PCV) values were significantly lower than control and OO group and non significantly lower than CYP+OO groups. Significantly higher total leucocyte count (TLC) values were recorded in CYP group compared to that of control, OO and CYP+OO groups.
Total protein and serum albumin were significantly reduced, while alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), blood urea nitrogen (BUN) and creatinine were significantly increased in CYP group compared to that of control and OO groups. CYP+OO displayed significantly higher values of total protein, significantly lower values of ALT, ALP and creatinine and non significantly higher values of albumin and non significantly lower values of AST and BUN compared to CYP group.
Pages: 1452-1455  |  303 Views  117 Downloads
How to cite this article:
Md. Rubina, D Madhuri, B Ramya and B Kalakumar. Olive oil ameliorates the serum biochemical and haematological changes induced by cypermethrin. The Pharma Innovation Journal. 2021; 10(12S): 1452-1455.

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