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Vol. 10, Special Issue 12 (2021)

Cardioprotective effect of aqueous leaf extract of Ficus religiosa Linn on 5-Fluorouracil induced toxicity in rats

Author(s):
Sushma Ghadigaonkar and A Gopala Reddy
Abstract:
Various parts of Peepal have been used for various medicinal purposes. The present study was planned to investigate the cardioprotective effect of aqueous leaf extract of Ficus religiosa against 5-Fluoroacil induced toxicity in rats. Male wistar albino rats were divided randomly into 6 groups of six rats each: control (Normal saline), 5-FU (20mg/kg IP), FRLE alone (400mg/kg oral), FRLE + 5-FU. After anaesthetized the animals on the last day, electrocardiograph was recorded and blood was analyzed for LDH, CK-MB, CRP and c-Troponin. The FRLE group showed decrease in QT duration and ST segment and increase in heart rate, QRS complex compared to the 5-FU group. Significant decrease in LDH, CK-MB, CRP and c-Troponin were observed as compared to the 5-FU. Result indicates that FRLE has cardioprotective effect against dose induced cardiotoxicity in rats.
Pages: 412-416  |  329 Views  105 Downloads
How to cite this article:
Sushma Ghadigaonkar and A Gopala Reddy. Cardioprotective effect of aqueous leaf extract of Ficus religiosa Linn on 5-Fluorouracil induced toxicity in rats. The Pharma Innovation Journal. 2021; 10(12S): 412-416.

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