Vol. 10, Special Issue 11 (2021)

Author(s):
Vijay Nain, Sonu Devi, Umed Singh Mehra and Amit Kumar

Abstract:
In the present investigation, six experimental trials were undertaken on clinically healthy male buffalo calves (Bubalus bubalis), 5 to 10 months of age, and weighing 60 to 140 kg to study the sedative action of of midazolam (0.2 mg/kg, i.m.). All the animals became ataxic within 3.33±0.76 minutes and went into lateral recumbency in 34±15.85 minutes after the administration of midazolam. There was a good muscle relaxation but no analgesia. The animals were standing with ataxia by 112.0±17.79 minutes and recovered after 183.5±17.79 minutes. The haemodyanamic changes showed that although there was about 15% reduction in MAP at 30 minute after administration of midazolam along with compensatory tachycardia and unaffected CVP, yet mean MAP value was never less than 120 mmHg. Slight increase in the amplitude of primary T-wave was observed in the electrocardiograms after midazolam administration. In conclusion, Midazolam (0.2 mg/kg, I.M.) can not be used for standing restraining of buffaloes because of severe ataxia caused by these drugs. However, good muscle relaxation achieved along with minimal cardiopulmanory effects should make use of this drug as a good preanaesthetic.