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Vol. 10, Special Issue 11 (2021)

Clinical and physiological changes in induction agents in drip form using guaifenesin and ketamine with or without dexmedetomidine under isoflurane anaesthesia for various surgeries in cattle

Author(s):
Neelkant, Dilipkumar D, Manjunath Patil, Bhagvantappa B, Venkatgiri and Pallavi
Abstract:
The present study was conducted in 12 clinical cases presented to Veterinary Clinical Complex, Veterinary College, KVAFSU, Bidar for the treatment of various surgical affections in cattle. The cattle were randomly divided into two groups consisting of six animals in each group. The group- I animals were administered guaifenesin at the dose rate of 50 mg / kg body weight intravenously as 5% solution in normal saline along with ketamine at the dose rate of 3 mg/ kg body weight intravenously as drip form and maintained with isoflurane (1-2%). The animals of group- II were administered with preanaesthetic dexmedetomidine hydrochloride (2.5 µg/kg, IV) after 5 minutes followed by guaifenesin at the dose rate of 50 mg / kg body weight intravenously as 5% solution in normal saline along with ketamine at the dose rate of 3 mg/ kg body weight intravenously as drip form and maintained with isoflurane (1-2%). Though the induction and recovery were smooth and uneventful in both groups, Induction time was significantly earlier in group-II animals.
The recovery time, Recovery time to assume sternal recumbency, Recovery time to standing position was significantly quicker in group-I animals. The degree of analgesia and muscle relaxation was significantly greater in group-II animals. Physiological parameters like heart rate shows significant difference between the groups. Respiratory rate and rectal temperature were decreased significantly at maximum depth of anaesthesia in both the groups. Respiratory depression and bradycardia were more severe in group-II animals compare to group-I animals. In the present study both the anaesthetic protocols provided satisfactory surgical plane of anaesthesia in cattle. However, guaifenesin and ketamine drip with dexmedetomidine under isoflurane combination was ideal to perform major surgeries in cattle without any complications.
Pages: 2485-2489  |  265 Views  82 Downloads
How to cite this article:
Neelkant, Dilipkumar D, Manjunath Patil, Bhagvantappa B, Venkatgiri and Pallavi. Clinical and physiological changes in induction agents in drip form using guaifenesin and ketamine with or without dexmedetomidine under isoflurane anaesthesia for various surgeries in cattle. The Pharma Innovation Journal. 2021; 10(11S): 2485-2489.

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