Clinical and physiological evaluation of induction combinations romifidine guaifenesin ketamine and dexmedetomidine guaifenesin ketamine under isoflurane anesthesia in cattle
Kumar Swamy, Dilipkumar D, Venkatgiri and Vinay P Tikare
The study was carried out to evaluate the feasibility of romifidine and dexmedetomidine sedation for guaifenesin, ketamine-isoflurane general anaesthesia for various surgeries in cattle. The study was carried out in 12 clinical cases of cattle presented to Veterinary Clinical Complex, Veterinary College Bidar for various surgical procedures. The cases were randomly divided into two groups consisting of six cattle in each group. The animals of group I were administered with romifidine (10 µg/kg,IV). The animals of group II were administered with dexmedetomidine hydrochloride (2.5µg/kg, IV) immediately followed by guaifenesin (50 mg/kg, 5% sol). After ten minutes, the anaesthesia was induced by administering ketamine hydrochloride (3 mg/kg, I/V) and maintained with isoflurane (1-2%) in both the groups. Though the induction and recovery were smooth and uneventful in both groups, faster onset of sedation, faster down time to sternal recumbency, early recovery time to regain sternal position and to assume standing position were noticed in cattle premedicated with romifidine than in cattle premedicated with dexmedetomidine for guaifenesin-ketamine-isoflurane general anaesthesia. Physiological and hemodynamic parameters like heart rate, respiratory rate, rectal temperature, mean arterial pressure and hemoglobin oxygen saturation were fluctuated within normal limit. Respiratory depression and bradycardia were more severe in cattle premedicated with romifidine when compared to cattle premedicated with dexmedetomidine.. In present study romifidine-guaifenesin-ketamine-isoflurane combination was ideal to perform major surgeries in cattle without any complications.
How to cite this article:
Kumar Swamy, Dilipkumar D, Venkatgiri and Vinay P Tikare. Clinical and physiological evaluation of induction combinations romifidine guaifenesin ketamine and dexmedetomidine guaifenesin ketamine under isoflurane anesthesia in cattle. The Pharma Innovation Journal. 2021; 10(11S): 1990-1992.