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Vol. 10, Special Issue 11 (2021)

A study on effect of filgrastim in severe leucopenia associated with hemorrhagic gastroenteritis in dogs

Author(s):
Sunil Punia, Tarun Kumar, Divya Agnihotri and Maneesh Sharma
Abstract:
Filgrastim is a recombinant Methionyl Human Granulocyte Colony-Stimulating Factor (r-metHuG-CSF) analog used to stimulate the proliferation and differentiation of granulocytes in humans. Young pups suffer from hemmoragic gastroenteritis (etiology may be viral like Canine Parvovirus or Canine Distemper Virus, bacterial like E.coli or parasitic) mainly associated with severe leukopenia and neutropenia. Neurtrophils being first line of defense against sepsis, decreased count may lead to increased mortality. In the present investigation eleven dogs with severe leukopenia and neutropenia when treated with Filgrastim @ 10 μg/ kg b.wt. s.c daily for three days along with other supportive treatment, was found to be effective in correcting the hematological picture within 48 hours of last dose of treatment and all the dogs showed fast recovery uneventfully.
Pages: 868-870  |  1021 Views  732 Downloads
How to cite this article:
Sunil Punia, Tarun Kumar, Divya Agnihotri and Maneesh Sharma. A study on effect of filgrastim in severe leucopenia associated with hemorrhagic gastroenteritis in dogs. The Pharma Innovation Journal. 2021; 10(11S): 868-870.

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