Role and distribution of aquaporins in renal system
Smriti Shukla, Gaurav Kumar, Amangeet Parashar and Sudha Saini
Aquaporins plays a major role in water movement in kidney, especially in renal medulla where ADH acts to reabsorb water and it is positively correlated with ADH different environmental temperature. AQP2 are involves in long term regulations of urinary concentration because the collecting ducts are importantly involved in the regulation of body water balance by vasopressin-regulated water reabsorption. Upregulation of AQP2 and AQP3 expression in both ureteral and urinary bladder tissue. The fold change expression of AQP3 was found to be highest expressed in ureter and urinary bladder as compare to AQP1 & AQP2 in summer season. AQPs may play a regulatory role in urothelial cell volume and osmolality and in determining the composition of ﬁnal urine. In the goats significant rise in the physiological reactions occurred during summer showing a positive correlation with the temperature and physiological responses so as to overcome the environment stress during different seasons of animals. The variations in the haematological counts, circulatory electrolytes, blood biochemical components observed in the goats during summer seasons depicting its thermo tolerance. The significant increase in the ADH and cortisol concentrations was high during summer showing a direct relationship with efficient water balancing mechanism in the body.
How to cite this article:
Smriti Shukla, Gaurav Kumar, Amangeet Parashar and Sudha Saini. Role and distribution of aquaporins in renal system. The Pharma Innovation Journal. 2020; 9(9S): 175-178.