Vol. 9, Special Issue 9 (2020)

Author(s):
Yadala Ravikumar, Madhuri D, Lakshman M, Gopalareddy A, Kalakumar B, Anilkumar B, Sawale GK, Sandhyarani K and Ramesh J

Abstract:
The study was aimed to know the cardiac toxicity by cadmium, chlorpyrifos and their combination in albino wistar rats. Experiment was carried out for 28 days. Group 1 - Control. Group 2 - Cadmium chloride (Cd) @ 22.5mg/ kg b.wt /per oral / day. Group 3 - Chlorpyrifos (CPF) @ 25 mg/ kg b.wt /per oral / day. Group 4 - Cadmium chloride (Cd) @22.5 mg + Chlorpyrifos (CPF) @ 25 mg/ kg b.wt /per oral / day. Heart showed mild to moderate congestion in groups 2 and 3 and moderate to severe in group 4 on 15^th and 29^th day of the experiment. Heart sections of control rats showed normal architecture. Group 2 rats on 15^th day of the experiment revealed loss of striations with swollen nuclei, inter fibrillar haemorrhages, mild congestion and focal lymphocytic infiltration; on 29^th day, lesions noticed were edema, inter fibrillar haemorrhages and degenerative changes. The sections of heart from group 3 rats revealed inter fibrillar haemorrhages on 15^th day and marked degenerative changes in the muscle fibres on 29^th day. Heart sections of group 4 rats on 15^th day revealed severe degenerative changes in the muscle fibres; on 29^th day, disruption of cardiac muscle fibres and focal areas of lymphocytic infiltration was observed. The adverse effects of combined CdCl₂ and CPF group (Group 4) were more severe than the individual groups (Group 2 & 3) due to synergistic action of the combined toxic agents.