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Vol. 9, Special Issue 9 (2020)

Cadmium and Chlorpyrifos induced histopathological alterations in the heart of male rats

Author(s):
Yadala Ravikumar, Madhuri D, Lakshman M, Gopalareddy A, Kalakumar B, Anilkumar B, Sawale GK, Sandhyarani K and Ramesh J
Abstract:
The study was aimed to know the cardiac toxicity by cadmium, chlorpyrifos and their combination in albino wistar rats. Experiment was carried out for 28 days. Group 1 - Control. Group 2 - Cadmium chloride (Cd) @ 22.5mg/ kg b.wt /per oral / day. Group 3 - Chlorpyrifos (CPF) @ 25 mg/ kg b.wt /per oral / day. Group 4 - Cadmium chloride (Cd) @22.5 mg + Chlorpyrifos (CPF) @ 25 mg/ kg b.wt /per oral / day. Heart showed mild to moderate congestion in groups 2 and 3 and moderate to severe in group 4 on 15th and 29th day of the experiment. Heart sections of control rats showed normal architecture. Group 2 rats on 15th day of the experiment revealed loss of striations with swollen nuclei, inter fibrillar haemorrhages, mild congestion and focal lymphocytic infiltration; on 29th day, lesions noticed were edema, inter fibrillar haemorrhages and degenerative changes. The sections of heart from group 3 rats revealed inter fibrillar haemorrhages on 15th day and marked degenerative changes in the muscle fibres on 29th day. Heart sections of group 4 rats on 15th day revealed severe degenerative changes in the muscle fibres; on 29th day, disruption of cardiac muscle fibres and focal areas of lymphocytic infiltration was observed. The adverse effects of combined CdCl2 and CPF group (Group 4) were more severe than the individual groups (Group 2 & 3) due to synergistic action of the combined toxic agents.
Pages: 18-20  |  91 Views  0 Downloads
How to cite this article:
Yadala Ravikumar, Madhuri D, Lakshman M, Gopalareddy A, Kalakumar B, Anilkumar B, Sawale GK, Sandhyarani K and Ramesh J. Cadmium and Chlorpyrifos induced histopathological alterations in the heart of male rats. The Pharma Innovation Journal. 2020; 9(9S): 18-20.
The Pharma Innovation Journal