Vol. 12, Issue 9 (2023)

Author(s):
M Lakshmi Namratha, M Lakshman, M Jeevanalatha and B Anil Kumar

Abstract:
The main clinical effects of consuming glyphosate are hepatotoxicity and renal toxicity. Vitamin C, a well-known antioxidant, helps to prevent cellular damage brought on by free radicals. The goal was to assess the impact of glyphosate on renal tissues in male albino Wistar rats at a dose of 500 mg/kg body weight (1/10 LD₅₀) and its amelioration by vitamin C at a level of 250 mg/kg body weight. For three weeks, the animals received daily oral treatments. The histology and ultrastructure pathologies of renal tissues, tissue oxidative stress parameters, and serum biochemical assays were investigated. In the treated group, there was a significant increase in the levels of the blood enzymes urea and creatinine. Malondialdehyde concentration, reduced glutathione, and superoxide dismutase levels were measured to assess oxidative stress in renal tissues. Kidney segment histopathology and ultrastructure pathology showed significant alterations. However, vitamin C treatment had a slight to moderately ameliorative effect on the examined parameters.