Vol. 12, Issue 9 (2023)

Author(s):
Mahanthesh MT, Ranjith D, Sudharani R, Kotresh Prasad, Sridhara JN, Ramesh BK, Jagjiwan Ram and Chethan T

Abstract:
Medicinal plants serve as valuable repositories of diverse photochemicals, offering remedies for a wide array of human ailments, including breast cancer. Their significant role extends to both modern and traditional medicine, exerting substantial physiological effects on the human body. The therapeutic potential of herbal treatments, enriched with an array of bioactive photochemicals, proves advantageous and reduced adverse effects compared to modern pharmaceuticals. Molecular docking has emerged as a crucial tool in drug discovery due to its cost-effectiveness and increasing popularity among researchers. The present investigation focuses on exploring the potential of Annonaceous acetogenins from Annona squamosa Linn. as anti-cancer agents, particularly targeting the estrogen receptor (ERα) protein (PDBID - 3ERT). The study employs ligands such as Annomuricin, Annosquacin I, Bullatacin, and Bullatalicin to interact with the ERα protein. Encouraging results are observed in terms of binding energy and inhibition constants, indicating their potential to impede the proliferation of breast cancer by targeting the ERα protein.