Vol. 12, Issue 8 (2023)

Author(s):
Ramya B, Anand Kumar A, Madhuri D, Gopala Reddy A and Shiva Kumar P

Abstract:
The present experiment was conducted to evaluate aerobic and anaerobic carbohydrate metabolic enzymes and histopathological changes in liver of experimentally induced hypothyroidism in rats. The study conducted in 21 days female Sprague drawly rats of total 96 number for 3 months. These rats were separated into8 groups with equal rats in each group. They were administered with: Group (Gp) 1: Euthyroidd Group 2: Hypothyroidism (Methimazole @ 00.02%) Gp 3: Hypothyroid + Levothyroxine Gp 4: root extract of Withania somnifera control @ 100 milli gram/Kilo gram body weight Gp 5: Hypothyroid + root extract of Withania somnifera @ 100 milli gram/Kilo gram body weight Gp 6: Shilajit control @ 100 milli gram/Kilo gram body weight Gp 7: Hypothyroid + a Shilajit @ 100 milli gram/Kilo gram body weight Gp 8: Hypothyroid + Withania somnifera root extract @ 100 milli gram/Kilo gram body weight + Shilajit @ 100 milli gram/Kilo gram body weight. The mean serum T₃, T₄ concentrations, G6PD and glycogen synthase in Gp-2 rats were significantly (p<0.05) lower. Serum TSH in the hypothyroid group was significantly (p<0.05) higher. Histopathological section revealed fatty degeneration, sinusoidal dilation, congestion, aggregation of lymphoid and franc necrosis. Lesions in ameliorating agent administered groups were mild to moderate. The present study indicated presence of physiological and functional effects on liver of hypothyroid rats in experimental model and usage of herbal drugs may have beneficiary role in treating hypothyroidism.