Vol. 12, Issue 12 (2023)

Author(s):
Roopa Bai RS, Sharanagouda Hiregoudar, Udaykumar Nidoni, Ramappa KT, Sushila Nadagoudar, Sushilendra and Krupanidhi

Abstract:
The objective of the present investigation was to study the hepatoprotective activity of supercritical fluid extract of Ailanthus excelsa leaf powder. The Ailanthus excelsa leaves were dried using dehumidified air dryer and milling was carried out using liquid nitrogen cooled pulverizer in order to retain the more bioactive compounds. The Ailanthus excelsa leaf extract was carried out using supercritical fluid extraction method at a pressure of 225 bar and temperature of 60 °C for extraction time of 120 min. The hepatoprotective activity of Ailanthus excelsa leaf extract was carried out for paracetamol (PCT) induced Albino rats. The effect of Ailanthus excelsa leaf extract on change in body weight, liver weight and biochemical parameters such as total bilirubin, SGOT, SGPT and ALP was studied. The change in body weight and liver weight of rats was found to be 4.50±0.63% and 4.21±0.05 g.100 g^-1, respectively for a dose of 400 mg.kg^-1 of body weight. The total bilirubin, SGOT, SGPT and ALP of rats were found to be 2.35±0.59, 52.97±0.43, 48.84±1.65 and 57.08±1.78 for a dose of 400 mg.kg^-1 of body weight. This was almost comparable to the groups treated with Silymarin a potent hepatoprotective drug used as reference standard and to the control group. Therefore, the study scientifically supports the traditional use of this drug for the treatment of liver disorders.