Vol. 12, Issue 1 (2023)

Author(s):
Mukta Singh, Himadri Saha, Ratan Kumar Saha and Paramveer Singh

Abstract:
The present study was conducted to elucidate the anti-oxidant effect of different herbal extract and the imidazole antifungal drug miconazole nitrate (MCZ). For the experiment, different herbs with medicinal properties were collected. Extracts were prepared from herbs and their antioxidant activity was evaluated using 1, 1-Diphenyl-2-picrylhydrazyl (DPPH) and Alkaline dimethyl sulfoxide (DMSO) radical scavenging assay. To find out the best extract of herbal plant by determining the antioxidant activity or their ability to scavenge free radicals, diverse varieties of herbal plants with medicinal properties were collected like Curcuma longa (turmeric) rhizome, Azadirachta indica (neem) leaves, Allium sativum (garlic) cloves, Zingiber officinale (ginger) rhizome. Herbal extract was prepared from the herbs obtained using ethanol and water as solvent. Ethanolic and aqueous extractions of all the selected plant parts were done and the yield percentages of the extracts were calculated. The highest yield obtained was of ethanolic garlic cloves extract (15.89%) and lowest being the aqueous neem leaves extract (6.34%). Among the different herbal extract, ethanolic turmeric extract was found to be more active and shows significantly higher activity compared to others, both in DPPH and alkaline DMSO scavenging assay whereas in ethanolic garlic extract has lower activity was observed.