Vol. 12, Issue 1 (2023)

Author(s):
Radhika R, Aziz Zarina, Ramnath V, Karthiayini K and Arun George

Abstract:
Several studies have been conducted in establishing the relationship between bone development and serum minerals such as calcium, phosphorus and the enzymes like alkaline phosphatase (ALP) as well as tartare -resistant acid phosphatase (TRAP). The role of magnesium in contributing to skeletal disorders is less known. In this study, the influence of serum ALP and TRAP in contributing to development of chronic skeletal disorders such as osteoporosis, hypertrophic osteodystrophy along with the serum concentration of calcium, phosphorus and magnesium will be discussed. Thirty healthy large breed dogs under 18 months of age were used for this study. Serum enzymes and phosphorus were estimated using fully automated biochemical analyzer. The levels of serum calcium and magnesium were detected with atomic absorption spectrophotometry (AAS). A significant increase in the serum ALP and TRAP were observed due to the intensive bone re-modelling in the course of bone disorders. The levels of calcium, phosphorus and magnesium were significantly lower in the diseased pups. Overall, this study helps to analyze the development of chronic skeletal disorders in growing pups and aids in early diagnosis and treatment.