Optimization and evaluation of bilayer tablet of clonidine
Author(s): Kundan Patel, Ramakant Sharma, Shabnam Khan, Jeevan Patel and Rakesh Patel
Abstract: The goal in designing sustained or controlled delivery systems is to reduce the frequency of the dosing or to increase the effectiveness of the drug by localization the action, reducing the dose required or providing uniform drug delivery. The primary objective of sustained release drug delivery is to ensure safety and to improve the efficacy of drugs as well as patient compliance. Bi-layer tablet is suitable for sequential release of two drugs in combination, separate two incompatible substances and also for sustained release tablet in which one layer is immediate release as initial dose and second layer is maintenance dose. The major objective of the work is the following: Clonidine is frequently administered up to 3 times in a day. So, the reducing dosing frequency by sustained release tablet, long term effect can be achieved by this dosage form, this drug help full in reducing high blood pressure and attention deficit hyperactivity disorder (ADHD), with the help of reduced fluctuation in plasma drug concentration, Reduction in side effect and dose related toxicity and patient compliance.
Kundan Patel, Ramakant Sharma, Shabnam Khan, Jeevan Patel, Rakesh Patel. Optimization and evaluation of bilayer tablet of clonidine. Pharma Innovation 2023;12(1):31-43. DOI: 10.22271/tpi.2023.v12.i1a.18104