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Vol. 12, Issue 1 (2023)

Diet-induced hyperlipidemia and hepatic steatosis in wistar albino male rats and its amelioration with whole grain flaxseeds (Linum usitatissimum) and green tea (Camellia sinensis)

Author(s):
Srinivasa Naik H, Srilatha CH, Sujatha K, Sreedevi B and Prasad TNVKV
Abstract:
Background: Hyperlipidemia is a disorder of lipid metabolism, characterized by elevated serum total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and very low-density lipoproteins cholesterol (VLDL-C) and decreased high-density lipoprotein cholesterol (HDL-C). Hyperlipidemia induces micro and macrovesicular hepatic steatosis, focal area of hepatic necrosis, portal fibrosis, biliary hyperplasia, and mononuclear cell infiltration. Flaxseeds (Linum usitatissimum) lignans (SDG), alpha-linolenic acid (ALA) and omega-3 fatty acid, and green tea (Camellia sinensis) polyphenols are known to have various health-beneficial effects including antihyperlipidemic properties. The beneficial effect of flaxseed and green tea was evaluated in experimentally induced hyperlipidemia and hepatic steatosis in wistar albino rats.
Method: Male Wistar albino rats were divided into six groups consisting of 12 rats each. 1% cholesterol along with 15% saturated edible oil to the 1000 g of standard rat chew diet (High cholesterol diet (HCD)) was used for induction of hyperlipidemia and hepatic steatosis. Whole grain flaxseed powder @ 7.5 g/kg/day and green tea @ 100 mg/kg/day were included in the HDC diet and maintained for 90 days along with controls.
Results: High cholesterol diet induced hyperlipidemia and hepatic steatosis. Flaxseed and green tea supplementation significantly reduced hyperlipidemia, increased all the cellular antioxidant enzymes, and reduced the level of thiobarbituric acid reactive substance (TBARS). Hepatic steatosis was greatly reduced in both flaxseed and green tea-supplemented groups. Green tea has shown better amelioration compared to flaxseed.
Pages: 715-722  |  107 Views  35 Downloads


The Pharma Innovation Journal
How to cite this article:
Srinivasa Naik H, Srilatha CH, Sujatha K, Sreedevi B, Prasad TNVKV. Diet-induced hyperlipidemia and hepatic steatosis in wistar albino male rats and its amelioration with whole grain flaxseeds (Linum usitatissimum) and green tea (Camellia sinensis). Pharma Innovation 2023;12(1):715-722.

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