Vol. 12, Issue 1 (2023)

Methods: The animals were randomly allocated in all the three models into five groups of six animals each and mice were received 1 ml/100 gm normal saline in group 1 and group 2 used standard drug for treated them as a positive control whereas group 50, 100 and 200 mg/kg extract doses given to the group 3, 4 and 5, respectively statistical significance of differences in the mean of fluid content of faces, number of defecation, intestinal fluid accumulation ratio, intestinal fluid weight and distance travelled by charcoal between groups was analyzed by software

Results: The Hydnora africana (Sub. Family-Hydnoraceae) at 100 and 200 mg/kg doses showed statistically significant (p<0.05) weight difference of the fluid content and inhibition of the frequency of defecation of the fluid content of the feces compared to the negative controls. The percentage inhibition for those doses of diarrheal feces was 43.65 and 53.54% respectively. In the standard drug the antisecretary of the extract in terms of fluid accumulation ratio was not found statistically significant compared to the negative control.

Conclusion: Root of Hydnora africana (Sub. Family-Hydnoroideae) has shown promising anti-diarrhoeal activity validates its use. Therewithal studies are needed and possibly the plant may serve as a strong source of new agent in the therapeutic armamentarium of diarrhea.