Genetic analysis of VP1 gene reveals involvement of vvIBDVs in disease outbreaks in vaccinated flocks of Kerala
Chandankar Vaidehi Deorao, Rajasekhar R, Nandhakumar D, Chintu Ravishankar, Sumod K, Hamza Palekkodan and Chaithra G
Recurrent outbreaks of Infectious bursal disease (IBD), become a major threat to poultry industry, worldwide. The disease mainly affects the pre developing B lymphocytes of bursa of Fabricius, causing severe immunosuppression in young chickens. Many outbreaks of IBD were observed in Kerala. The current study was carried out with the aim to analyse the involvement of genetic nature of infectious bursal disease virus which caused outbreak in vaccinated flocks of Kerala. Total 14 bursal samples were collected from flocks suspecting for IBD which were vaccinated against IBD. The amino acid analysis of VP1 gene of these isolates reveals that out of 14 isolates, 11 isolates showed TDN amino acid triplet in their sequences which is characteristic of vvIBDV. Three isolates showed NEG amino acid triplet, which is characteristic of non vIBDV. This is the first genetic analysis of VP1 gene revealing the involvement of vvIBDVs from the vaccinated flocks of Kerala.
How to cite this article:
Chandankar Vaidehi Deorao, Rajasekhar R, Nandhakumar D, Chintu Ravishankar, Sumod K, Hamza Palekkodan, Chaithra G. Genetic analysis of VP1 gene reveals involvement of vvIBDVs in disease outbreaks in vaccinated flocks of Kerala. Pharma Innovation 2022;11(5):2380-2383.