Abstract:The aim of the study was to determine the phytochemicals presence in the plant extract of Anogeissus leiocarpus and analyze the extract using GC-MS analysis. The stem bark of Anogeissus leiocarpus was collected, dried and grounded. Extraction was conducted using successive extraction technique with three different solvents that include n-hexane, methanol, and distilled water. The extract was then screened for the presence of phytochemicals that include saponins flavonoids phytosterols and tannins phenols. GC-MS analysis of the extract was also conducted in order to validate the qualitative phytochemical test. The result of the phytochemical screening revealed the presence of saponins, phytosterols, and tannins phenols, whereas the GC-MS analysis of the extract showed the presence of 29 chemical compound that include Ethanimidic acid, ethyl ester, Chloroformate, 1, 2-Propanediol diformate, (R)-(-)-2-Amino-1-propano, 1H-Imidazole-4-ethanamine, 2-methy, Furan, 2, 5-dimethyl, Thiirane, 2, 3-dimethyl-, trans, R(-)-1-Cyano-2-methylpyrrolidine, 2,4-Dihydroxy-2, 5-dimethyl-3(2H)-furan-3-one, Pentanoic acid, 4-methy, 4H-Pyran-4-one, 2, 3-dihydro-3, 5-dihydroxy-6-methyl, 4-Piperidinemethanamine, 5-Hydroxymethylfurfural, 1-Allyl-cyclohexane-1, 2-diol, 1, 2, 3-Benzenetriol Sucrose, Cyclohexane, 1-(1,5-dimethylhexyl)-4-(4-methylpentyl. The findings of this study suggest the use of stem bark extract of Anogeissus leiocarpus for treatments of various ailments, since it contain various compounds which have various medicinal properties.