Pharmacokinetic profile of marbofloxacin following oral administration in broiler chickens
Patel AR, Patel HB, Sarvaiya VN, Singh RD, Patel HA, Vaghela SH, Tukra S and Mody SK
Marbofloxacin is a synthetic, third-generation fluoroquinolone drug, having concentration-dependent bactericidal activity and a broad spectrum antimicrobial activity against Gram-negative and Gram-positive bacteria. Looking to the clinical potential of marbofloxacin to treat bacterial infections in poultry species, the present study was planned to investigate its pharmacokinetic profile following single dose oral administrations at a dose of 5 mg/kg body weight in eight broiler chickens. Plasma samples were analyzed for marbofloxacin concentration by Ultra High Performance Liquid Chromatography (UHPLC) with UV detector. The mean value of elimination rate constant (β) was 0.17 ± 0.03 h-1. The mean value of its corresponding half-life (t½β) was calculated to be 4.89 ± 0.65 h. The area under curve (AUC) of plasma marbofloxacin concentration versus time was found to be 14.70 ± 2.94 μg•h/ml. The mean values of mean residence time (MRT), apparent volume of distribution (Vd(area)) and total body clearance (ClB) were 7.48 ± 0.94 h, 2.80 ± 0.40 L/kg and 0.47 ± 0.11 L/h/kg, respectively. Marbofloxacin following single dose oral administration (5 mg/kg) showed favourable pharmacokinetic profile to be used clinically in broiler chickens.
How to cite this article:
Patel AR, Patel HB, Sarvaiya VN, Singh RD, Patel HA, Vaghela SH, Tukra S, Mody SK. Pharmacokinetic profile of marbofloxacin following oral administration in broiler chickens. Pharma Innovation 2022;11(11):22-25.