Vol. 11, Issue 11 (2022)

Marbofloxacin is a synthetic, third-generation fluoroquinolone drug, having concentration-dependent bactericidal activity and a broad spectrum antimicrobial activity against Gram-negative and Gram-positive bacteria. Looking to the clinical potential of marbofloxacin to treat bacterial infections in poultry species, the present study was planned to investigate its pharmacokinetic profile following single dose oral administrations at a dose of 5 mg/kg body weight in eight broiler chickens. Plasma samples were analyzed for marbofloxacin concentration by Ultra High Performance Liquid Chromatography (UHPLC) with UV detector. The mean value of elimination rate constant (β) was 0.17 ± 0.03 h^-1. The mean value of its corresponding half-life (t_½β) was calculated to be 4.89 ± 0.65 h. The area under curve (AUC) of plasma marbofloxacin concentration versus time was found to be 14.70 ± 2.94 μg•h/ml. The mean values of mean residence time (MRT), apparent volume of distribution (Vd_(area)) and total body clearance (Cl_B) were 7.48 ± 0.94 h, 2.80 ± 0.40 L/kg and 0.47 ± 0.11 L/h/kg, respectively. Marbofloxacin following single dose oral administration (5 mg/kg) showed favourable pharmacokinetic profile to be used clinically in broiler chickens.