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Vol. 11, Issue 1 (2022)

Haemato-biochemical effects of intraperitoneal ropivacaine and ropivacaine - dexmedetomidine for pain management in pigs undergoing herniorrhaphy

Author(s):
Gokulraj S, Hitesh Bayan, Bedanga Konwar, Prava Mayengbam and JB Rajesh
Abstract:
Different types of laparotomy procedures are common in pigs as they are used as experimental animal model for the biomedical research. In field level, surgeries like caesarean sections, spaying and hernia correction are also usually performed. But the uses of high standard perioperative as well as post-operative analgesic drugs are limited in those animals. This study was conducted for the evaluation of haematobiochemical changes with intraperitoneal ropivacaine and dexmedetomidine in 18 Clinical cases of pigs which were operated for the correction of either umbilical or ventral hernia. The animals were randomly divided into three groups. All the animals were premedicated with meloxicam and anaesthesia was induced and maintained with diazepam-ketamine combination. Intraperitoneal administration of ropivacaine or ropivacaine with dexmedetomidine or normal saline was given in the treatment groups. The blood samples were collected from superficial ear vein before administration of pre medication (zero minute), after induction of anaesthesia (30 minutes), after intraperitoneal infusion (1 hour) and postoperatively after 24 hours for the haemato-biochemical evaluation.
All the haematological as well as serological parameters except serum creatine kinase and cortisol were fluctuated within the physiological limit and animal did not show any sign of anaesthesia related complications after intraperitoneal administration of the drugs.
Pages: 1250-1254  |  240 Views  40 Downloads


The Pharma Innovation Journal
How to cite this article:
Gokulraj S, Hitesh Bayan, Bedanga Konwar, Prava Mayengbam, JB Rajesh. Haemato-biochemical effects of intraperitoneal ropivacaine and ropivacaine - dexmedetomidine for pain management in pigs undergoing herniorrhaphy. Pharma Innovation 2022;11(1):1250-1254.

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