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Vol. 11, Issue 1 (2022)

Gastroretentive effervescent floating tablets of diclofenac sodium and effect of different polymers on drug release

Author(s):
Dr. Rakesh Kumar Sharma, Darsh Gautam and Ritesh Rana
Abstract:
Floating dosage forms are formulated with a lower density than gastric contents in order to achieve a longer residence time in the stomach, which results in the system floating on the gastric contents of the stomach for a longer period of time without affecting the gastric emptying rate. The objective of this study was to manufacture and evaluate an in-vitro floating tablets using diclofenac sodium. The solid dosage forms, tablets were made using a direct compression method using effervescent technology & matrix forming Polymers. sodium bicarbonate, citric acid, HPMC and microcrystalline cellulose (MCC) used as excipients, Carbapol was used to decrease drug release, and sodium bicarbonate and citric acid were used to achieve effervescence. Buoyancy, Floating time & dissolution rate of five formulations was made with different concentrations of HPMC, Carbapol, and MCC was determined. The optimized F4 formulation released 231.0 percent of the drug in 6 hours with a floating lag time of 56 seconds, while the unoptimized F1 formulation released 492.2 percent of the drug in 6 hours with a floating lag time of 31 seconds. it can be maintained by increasing the polymer concentration according to an in vitro dissolution study.
Pages: 1009-1012  |  616 Views  396 Downloads


The Pharma Innovation Journal
How to cite this article:
Dr. Rakesh Kumar Sharma, Darsh Gautam, Ritesh Rana. Gastroretentive effervescent floating tablets of diclofenac sodium and effect of different polymers on drug release. Pharma Innovation 2022;11(1):1009-1012.

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