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Vol. 10, Issue 7 (2021)

Antimicrobial and antimycotoxigenic activities of (3s)-3, 6, 7-trihydroxy-α-tetralone isolated from endophytic Phoma moricola

Author(s):
Akbar Basha Roshan and Devihalli Chikkaiah Mohana
Abstract:
Endophytic fungi are known to biosynthesis a plethora of bioactive secondary metabolites with promising antimicrobial activities. The present investigation evaluated the antimicrobial and antimycotoxigenic activities of the bioactive compound (3S)-3, 6, 7-trihydroxy-α-tetra lone (TT) isolated from Phoma moricola an endophytic fungus of Withania somnifera. The compound TT showed concentration-dependent broad-spectrum antimicrobial and anti-mycotoxin activities. The biosynthesis of aflatoxin B1 (AFB1) from Asprgilllus flavus and fumonisin B1 (FB1) from Fusarium verticillioides were strongly inhibited by TT at 200 µg/mL. The compound TT significantly interferes A. flavus and E. coli growth by inhibiting membrane-specific cellular ergosterol biosynthesis and release of potassium ions, respectively. The docking study confirms that TT strongly active against the enzyme polyketide synthase, with a docking score of -6.77 kcal/mol units. The obtained results confirm the antimicrobial and antimycotoxin activities of TT; hence this compound could be explored as a green eco-friendly strategy for managing pathogenic microbial and mycotoxins contamination in food- and feedstuffs.
Pages: 852-860  |  341 Views  111 Downloads


The Pharma Innovation Journal
How to cite this article:
Akbar Basha Roshan, Devihalli Chikkaiah Mohana. Antimicrobial and antimycotoxigenic activities of (3s)-3, 6, 7-trihydroxy-α-tetralone isolated from endophytic Phoma moricola. Pharma Innovation 2021;10(7):852-860.
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