Vol. 10, Issue 3 (2021)

Author(s):
B Harish, P Shivakumar, BDP Kala Kumar, B Ramya, M Usha Rani, B Anil Kumar and Venkata Rao KV

Abstract:
We investigate the protective effects of resveratrol and vitamin-E against 5-flourouracil induced hepatotoxicity in rats. Experimental rats were treated with 5-FU (20 mg/kg b.wt.) i.p. on day 1, 3, 7 to induce hepatotoxicity, evident by significant (p< 0.05) increase in the levels of ALT, AST, TBARS, protein carbonyls, TNF-α, while significant (p< 0.05) decrease in the levels of GSH, IL-10. Liver of 5-FU treated rats showed marked infiltration with inflammatory cells, moderate congestion in the central vein, mild vacuolations between hepatocytes and moderate necrosis. There is mild sinusoidal dilation, disorganized hepatocytes and periportal necrosis. Resveratrol and Vitamin-E treatment markedly reversed the changes induced by 5-FU in all parameters. These data concluded that Resveratrol and Vitamin-E had protective effects against 5-FU induced hepatotoxicity in rats.