Vol. 10, Issue 3 (2021)

Author(s):
Korzh NV and Ostrovskyy MM

Abstract:
Management of patients with chronic obstructive pulmonary disease is the prerogative not only of pulmonologists, but also of physicians and family doctors. This problem still remains the most common chronic human disease, which is widespread in both developed and developing countries due to its high prevalence, progressive course, and reduced life expectancy of patients. The risk of COPD development, especially in the elderly, may be attributed to socio-economic causes and low living standards, and at the same time its incidence and severity of the course and its prognosis are often determined by the influence of concomitant pathology on the frequency of exacerbations, so the problem of comorbidity is becoming increasingly important. The objective of this study was to determine the diagnostic significance of serum levels of CRP, TNF-α and leptin in exacerbation phase of COPD (III degree of bronchial obstruction) in overweight patients in order to optimize management and treatment strategies. The study involved the examination of 45 overweight patients: 18 of them were in the phase of remission; 27 overweight patients were in the phase of exacerbation of the pathology, and were in turn divided into 2 subgroups: patients of subgroup I (n = 15) were administered xanthine only, and patients of subgroup II (n = 12) have also agreed to modify their life style. The research findings showed a decrease in all the studied indices on the 10th day. Data obtained after three months of treatment were more significant, especially in patients of subgroup II. Thus, overweight has a negative influence on the course of COPD (III degree of bronchial obstruction), and the use of comprehensive therapy with xanthine and lifestyle modifications in the treatment of this pathology improves clinical symptomatology and has a positive effect on the indices of inflammatory activity, which was manifested by a significant decrease in CRP, TNF-α, and leptin levels and contributed to the improvement of their quality of life.