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Vol. 10, Issue 3 (2021)

Formulation and critical evaluation of piroxicam gel

Author(s):
Jadhao Umesh T, Rathod Sayali P, Dhembre Gunesh N, Sable Shital D and Lokhande Sneha S
Abstract:
The present study has been undertaken with the aim to formulate gel containing Piroxicam by using gelling agents like cabopol-940 and HPMC with different penetration enhancers. Five different formulae were prepared and characterized physically in term of color, spreadability, pH, drug content and rheological properties. The value of spredability indicated that these gels are easily spreadable by small amount of shear. Viscosity of gel was found in range of 36000-48900 cps. In vitro drug release was evaluated using Franz diffusion cell. The results of in vitro drug release and its permeation studies showed that the highest values was from F1 (86% of drug released after 8 hr.). Carrageenan induced rat paw oedema model was used for the evaluation of the anti-inflammatory activity of the gels. The rheological behaviour of the prepared formulae showed shear-thinning flow indicating structural breakdown of the existing intermolecular interactions between polymeric chains.
Pages: 89-94  |  845 Views  513 Downloads


The Pharma Innovation Journal
How to cite this article:
Jadhao Umesh T, Rathod Sayali P, Dhembre Gunesh N, Sable Shital D, Lokhande Sneha S. Formulation and critical evaluation of piroxicam gel. Pharma Innovation 2021;10(3):89-94.
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