Vol. 10, Issue 2 (2021)

Author(s):
Md Quamuddin, Sokinder Kumar, Pawan Kumar, Khalid Iqbal and Md Rafiul Haque

Abstract:
In the current article, it is investigated the protective activity of Cinnamomum zeylanicum aqueous extract (CZAE) against paracetamol (PCM) induced nephrotoxicity in albino rats. Wistar albino rats (150-200 g) were divided into six groups and toxicity was induced by APAP (750 mg/kg, p.o, 10 days). CZAE (100, 200 mg/kg, p.o), silymarin (100 mg/kg, p.o) was administered to rats 2 h before PCM administration. Various biochemical parameters like serum urea, serum creatinine, uric acid and total protein levels were measured. Histopathological analyses of kidney injury were also studied. Treatment with CZAE (100, 200 mg/kg, bw) significantly (p˂0.001, p˂0.01) decreased serum urea and serum creatinine as compared with PCM rats. Decreased levels of uric acid and total protein were also significantly restored with CZAE treatment. Apart from these, CZAE treatment also reduced histopathological alteration induced by paracetamol in kidney. It was concluded that CZAE have a strong nephroprotective activity against PCM induced nephrotoxicity in albino rats.