Vol. 10, Issue 11 (2021)

Author(s):
Anubhuti Pasrija, Harvinder Popli, Ranjan Mitra and Chhavi Singla

Abstract:
Senescence is a cellular response that is characterized by a stable growth arrest that limits the proliferation of aged or damaged cells. There are several biomarkers, which are associated with the cellular senescence. Β-Galactosidase is one such biomarker which is widely used to detect cellular senescence in vitro. This marker is present in senescent cells only and is a reliable marker for senescent cell detection. Brihat Panchamool is a part of Dashmoola herb which is a combination of ten ayurvedic herbs i.e. Bilva, Patala, Agnimantha, Shyonaka, Gambhari, Bruhati, Kantakari, Prishniparni, Shalparni, Gokshura, where part used are moola of all the drugs in a group. The first five herbs of Dashmoola are collectively called Brihat Panchamoola which is used traditionally in various ayurvedic formulations like Dashmolarishta, Dashmool ghritam, chywanprash, Mahanarayan Tail etc. The present study has been undertaken with a view to establish the in vitro anti-ageing activity of young roots and bark of Brihat Panchamoola species. The aqueous extracts of roots and bark showed profound anti-ageing potential.