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Vol. 10, Issue 1 (2021)

A computational approach to use the FPP capped ZnO nanoparticle as an ameliorative drug in testicular toxicity

Author(s):
S Pavithra, A Karthikeyan and S Shanmuganathan
Abstract:
Pectins are complex polysaccharides of the plant cell wall and generally recognized as safe as food ingredient and used as an adsorbent, antibacterial and antitumour substance. Similarly, Nanoparticles of ZnO proven to be antioxidants in earlier studies. Testicular toxicity is the major complication of cancer chemotherapy and it affects the spermatogenesis and steroidogenesis pathway. Testosterone is a major hormone involved in male fertility. A new in silico approach was carried out using a combination of Fractionated pectin powder (FPP) capped nZnO with the enzymes involved in the testosterone synthesis pathway. The docking scores were analysed and the best ligand-target interactions were identified. Hence present study projects the positive role of FPP capped nZnO with the steroidogenic enzymes.
Pages: 770-772  |  143 Views  35 Downloads


The Pharma Innovation Journal
How to cite this article:
S Pavithra, A Karthikeyan, S Shanmuganathan. A computational approach to use the FPP capped ZnO nanoparticle as an ameliorative drug in testicular toxicity. Pharma Innovation 2021;10(1):770-772.
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