Vol. 10, Issue 1 (2021)

Author(s):
Md. Rafiul Haque, SH Ansari and Mahfuz Alam

Abstract:
Zangiber officinale, commonly called as ginger, its rhizome part is a very important for its traditional uses due to presence of oleoresin and volatile oil. It belongs to the family Zangiberaceae. The objectives of current study are to determine the quality and evaluation of anti-lipase activity and lipid profile in Zangiber officinale on obese rat modal. Determination of quality of Zangiber officinale Roscoe rhizome is done with the help of microscopical and physiochemical studies. The composition of ginger oil was analyzed by gas chromatography (GC) and gas chromatography mass spectroscopy (GCMS). Zangiber officinale distillate (ZD) was prepared for the study of lipid profile and pancreatic lipase activity. All these physiochemical values and microscopical observations were under pharmacopeia’s limits and observation. Volatile oil content was 1.2 ± 0.03%w/w, and 53 components were identified. Camphene (18.28%), para-cineole (10.02%), zingiberene (6.12%), and cuminaldehyde (2.17%) were as major components. After end of the treatment, Zangiber officinale distillate (7.75 ml/kg, twice a day) treatments showed significant reduction in serum lipids. But ZD did not significantly alter the pancreatic lipase activity. These results recommend that ZD have strong hypolipidemic activity without inhibition of pancreatic lipase in HFD induced obese rat model.