Toll Free Helpline (India): 1800 1234 070

Rest of World: +91-9810852116

Free Publication Certificate

Vol. 10, Issue 1 (2021)

Xylo-oligosaccharides regulated the key enzymes and receptors involved in cholesterol metabolism in hypercholesteremic hamsters

Author(s):
Abdullah Abdulaziz Abbod Abdo, Chengnan Zhang and Xiuting Li
Abstract:
High levels of total cholesterol (TC) and low-density lipoprotein-cholesterol (LDL-C) in the blood are the major risk factors for coronary heart disease and atherosclerosis. In our previous study, we found that Xylo-oligosaccharides (XOS) were down-regulated plasma cholesterol and non-high-density lipoprotein-cholesterol (non-HDL-C) by the promotion of acidic sterols excretion. The underlying mechanism by how supplementation of XOS improved excretion of acidic sterols remains vague. Therefore, this study was designed to examine the role of xylooligosaccharides in the regulation of key enzymes and receptors in cholesterol metabolism including cholesterol 7α-hydroxylase (CYP7A1), liver X receptor α (LXRα), 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), and sterol regulatory element-binding protein-2 (SREBP-2). In this study, enzymes and receptors were measured in hamsters fed for six weeks one of three diets: low cholesterol diet (LCD), high cholesterol diet (HCD), and HCD plus 5% xylooligosaccharides (XOS).
The results of this study showed that protein levels of CYP7A1(The rate-limiting enzyme for bioconversion of cholesterol to acidic sterols in the liver) and LXRα (CYP7A1 regulator) were up-regulated by xylooligosaccharides supplementation. By contrast, HMG-CoA (The major regulatory enzyme in cholesterol biosynthesis), and SREBP-2 (SREBP-2 is a master nuclear transcription factor for regulation of HMGCR) in hepatic hamsters were down-regulated by xylooligosaccharides addition. Therefore, the present data indicate that XOS use as nutraceuticals or functional foods may be a strategy for the regulation of hypercholesteremia in humans.
Pages: 701-704  |  227 Views  86 Downloads


The Pharma Innovation Journal
How to cite this article:
Abdullah Abdulaziz Abbod Abdo, Chengnan Zhang, Xiuting Li. Xylo-oligosaccharides regulated the key enzymes and receptors involved in cholesterol metabolism in hypercholesteremic hamsters. Pharma Innovation 2021;10(1):701-704.

Call for book chapter