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Vol. 10, Issue 1 (2021)

Biochemical studies on induced hyperlipidemia and its amelioration using aged garlic extract in Wistar rats

Author(s):
Shashidhar Ballari, ML Satyanarayana, Suguna Rao, HD Narayanaswamy, Prakash Nadur and V Girishakumar
Abstract:
The effect of aged garlic extract on different biochemical parameters was studied. The study included 72 Wistar albino rats, divided 12 in each group into six groups. Group I served as normal control group. To group II high fat diet was given as diet control. Rats in the group III were administered aged garlic extract at 200mg/kg bw. Group IV rats were administered aged garlic extract at 200mg/kg.bw with high fat diet. Rats in group V were administered atorvastatin at 15mg/kg.bw with high fat diet. The group VI rats with aged garlic extract and atorvastatin at half dose (100mg and 7.5mg/kg respectively) with high fat diet. The duration of the study was for 56 days and the blood samples were collected at 42nd and 56th day of study for evaluation. The high fat diet induced hyperlipidemia altered biochemical parameters; significant increase (P<0.05) total cholesterol, triglycerides, LDL-c, VLDL-c and reduction in the HDL-c. The serum enzymes like ALT, AST were also increased, but no change was observed in the serum levels of GGT, BUN and creatinine. The aged garlic extract treatment at the dosage used showed moderate improvements in the mean (┬▒SE) values of lipid profile and serum enzymes, this suggested that the aged garlic extract could be used for improving the high fat diet induced serum biochemical abnormalities.
Pages: 435-438  |  312 Views  89 Downloads


The Pharma Innovation Journal
How to cite this article:
Shashidhar Ballari, ML Satyanarayana, Suguna Rao, HD Narayanaswamy, Prakash Nadur, V Girishakumar. Biochemical studies on induced hyperlipidemia and its amelioration using aged garlic extract in Wistar rats. Pharma Innovation 2021;10(1):435-438. DOI: 10.22271/tpi.2021.v10.i1f.5559
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