Viral miniproteins: Immunobiology- A special emphasis on RNA viruses role in replication and virulence
Manikandan R, Bindu S, Dinesh M, Jigarji C Thakor, S Shanmuganathan and Gollapalli Sivarama Krishna
Viruses encode short transmembrane proteins that play vital roles in virus replication or virulence. These viral miniproteins are often short less than 100 amino acids. Some of these proteins oligomerize in membranes and form ion channels (viroporins). Viroporins are small proteins with at least one amphipathic helix that constitutes its transmembrane domain, spanning lipid membranes. Viroporins induced host responses are activation of inflammasome, apoptosis, and autophagy. Viroporins place an important role in viral entry, uncoating, replication, assembly and release in the viral life cycle. Most of the viral mini proteins were discovered by viral genome sequencing. The rational design of specific antiviral drugs can also be formulated against the viral miniproteins which play a very integral role in the viral lifecycle. Further scientific research strategies are required to counteract the immunobiology mediated by the viral miniproteins and may also for discovering the mutants lacking viral miniproteins attenuated vaccines.
How to cite this article:
Manikandan R, Bindu S, Dinesh M, Jigarji C Thakor, S Shanmuganathan, Gollapalli Sivarama Krishna. Viral miniproteins: Immunobiology- A special emphasis on RNA viruses role in replication and virulence. Pharma Innovation 2021;10(1):212-216.