Evaluation of anti-diabetic, anti-hyperlipidemic and anti-oxidant properties of hydro-alcoholic extract of Euphorbia cotinifolia
Darshan R Agrawal, Sourabh Jain and Karunakara R Shukla
Indian people have 77 million belong to India. Diabetes describes a group of metabolic diseases characterized by high blood sugar levels and has hyperlipidemia condition. The present study was carried out to investigate the antidiabetic, antihyperlipidemic and antioxidant activity properties of hydroalcoholic extract of Euphorbia cotinifolia stem. Streptozotocin induced diabetic Wister rats were used in this study consisting of five groups of five animals each. Groups (1) normal control, (2) diabetic control, (3) HEEC 300mg/kg b.w, (4) HEEC 600mg/kg b.w (5) Glibenclamide respectively. Fasting blood sugar was recorded on 1st, 7th, 14th, 21st and 28th day. At the end of the experiment lipid profile and levels of antioxidants were determined. Safety profile of both extracts was evaluated using acute and chronic toxicity studies in streptozotocin-induced diabetic male rats. Higher dose of HEEC and glibenclamide significantly lowered blood glucose level from 7th day onwards however glibenclamide was found to be more effective but lower dose not show significant decrease blood glucose on same day. HEEC both dose and standard show significant decrease glucose remain days. Glibenclamide and both dose of stem HEEC extract significantly reduced the total cholesterol (Including HDL and LDL), triglyceride levels and significantly increased the high-density lipoprotein cholesterol level. HEEC possesses significant anti-diabetic, hypolipedimic and antioxidant properties. This study supports the traditional use of Euphorbia cotinifolia stem in diabetes.
How to cite this article:
Darshan R Agrawal, Sourabh Jain, Karunakara R Shukla. Evaluation of anti-diabetic, anti-hyperlipidemic and anti-oxidant properties of hydro-alcoholic extract of Euphorbia cotinifolia. Pharma Innovation 2020;9(9):21-25.