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Vol. 9, Issue 9 (2020)

Development and validation of analytical method for simultaneous estimation of paroxetine HCL and etizolam

Author(s):
Hemangi Parekh and Rajashree Mashru
Abstract:
Paroxetine HCl and Etizolam are anxiolytics. Both drugs are used to treat anxiety, mental disorder etc. In combination of both the drug shows synergistic effect. UV Spectrometry and RP-HPLC method has been developed for paroxetine HCl and etizolam in marketed mixture. Absorbance Correction method, First derivative Zero Crossing Point (ZCP) and First derivative Q-Ratio method was developed base on UV Spectrometry. In RP-HPLC, mobile phase consist of ACN: phosphate buffer (50mm, 3.5pH) in ratio of 60:40. Drugs were detected at 249nm wavelength using flowrate 1mL/min.
Pages: 145-153  |  581 Views  133 Downloads


The Pharma Innovation Journal
How to cite this article:
Hemangi Parekh, Rajashree Mashru. Development and validation of analytical method for simultaneous estimation of paroxetine HCL and etizolam. Pharma Innovation 2020;9(9):145-153.

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