Vol. 9, Issue 9 (2020)

Author(s):
Hemangi Parekh and Rajashree Mashru

Abstract:
Paroxetine HCl and Etizolam are anxiolytics. Both drugs are used to treat anxiety, mental disorder etc. In combination of both the drug shows synergistic effect. UV Spectrometry and RP-HPLC method has been developed for paroxetine HCl and etizolam in marketed mixture. Absorbance Correction method, First derivative Zero Crossing Point (ZCP) and First derivative Q-Ratio method was developed base on UV Spectrometry. In RP-HPLC, mobile phase consist of ACN: phosphate buffer (50mm, 3.5pH) in ratio of 60:40. Drugs were detected at 249nm wavelength using flowrate 1mL/min.