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Vol. 9, Issue 7 (2020)

Formulation and evaluation of granules based on trunks barks extracts of Anogeissus leiocarpus (DC) Guill. et Perr. (Combretaceae) intended for the development of phytomedicines for the treatment of hypertension

Author(s):
Salfo Ouédraogo, Charles B Sombié, Sidiki Traoré, Tata Kadiatou Traoré, Mathieu Nitiéma, Lazare Belemnaba, Josias BG Yameogo, Hermine Z Diawara, Noufou Ouédraogo, Marius Lompo, Sylvin Ouédraogo and Rasmané Semdé
Abstract:
Quality control as well as the appropriate integration of modern scientific technique and traditional knowledge are important for promoting traditional remedies. Thus, preliminary quality control studies of extracts of Anogeissus leiocarpus concluded that there was a need to improve the rheological properties. Granulation improves properties such as texture, porosity or wettability. It reduces the amount of dust during handling. Ten (10) formulations were produced, the compositions of which were varied by the content of corn starch, Polyvinylpyrolidone and magnesium stearate. All the granules were prepared by wet granulation. After the drying process, the granules were sieved through a 1.6 mm mesh screen to standardize the particle size. The dust was sieved through 1.2 mm and these particles were again granulated. All quality control tests have been carried out in accordance with the European Pharmacopoeia 6.0. The average disintegration times of the formulations prepared were all less than 10 minutes. The residual humidity of the various pellets was less than 10%. The granules formulated F2 and F3 were less friable. The granules had a good flow time. All the granules were hygroscopic. The solubility tests carried out on the formulations showed that the content of F3 tracer was greater than 85% after 45 min. Microbial controls met the standards of European Pharmacopoeia 6.0 for preparations for oral administration containing raw materials of natural origin. The F3 formulations had the best characteristics in accordance with the recommendations of the European Pharmacopoeia 6.0.
Pages: 58-63  |  169 Views  6 Downloads
How to cite this article:
Salfo Ouédraogo, Charles B Sombié, Sidiki Traoré, Tata Kadiatou Traoré, Mathieu Nitiéma, Lazare Belemnaba, Josias BG Yameogo, Hermine Z Diawara, Noufou Ouédraogo, Marius Lompo, Sylvin Ouédraogo, Rasmané Semdé. Formulation and evaluation of granules based on trunks barks extracts of Anogeissus leiocarpus (DC) Guill. et Perr. (Combretaceae) intended for the development of phytomedicines for the treatment of hypertension. Pharma Innovation 2020;9(7):58-63.
The Pharma Innovation Journal