Vol. 9, Issue 7 (2020)

Purpose of the study: is to develop a programme of preventive treatment measures at different ages of puberty in adolescent girls with diffuse endemic goiter and menstrual disorders.

Materials and methods of research: 120 patients with menstrual dysfunction on the background of diffuse endemic goiter were divided into two groups. The key points of the optimized treatment complex in the main group were the use of Agnus castus extract. The girls in late puberty were offered low-dose combined oral contraceptives – ethinylestradiol 0.02 mg and drospirenone 3 mg in 24+4 schedule, in combination with vitamin B8 (inositol).

Results of the study and their discussion: The development of menstrual disorders (irregular periods), uterine bleeding, hypomenstrual syndrome and secondary amenorrhea, excess body weight in over half of the patients, polycystic changes in the structure of the ovaries were revealed. The scientific search allowed to note after 12 months from the beginning of therapy the decrease of a palpable struma by 1.5 times, the number of cases of galactorrhea and mastopathy decreased by 1.8 times, the normalization of hormonal imbalance, which allowed restoring menstrual function and physiological ovulatory rhythm cycles by 91.7%

Conclusions: The research results confirm that teenage girls with diffuse endemic goiter are at high risk for developing menstrual disorders but application of advanced diagnostic and preventive medical measures, enhanced by us, can improve their effectiveness and prevent reproductive disorders.