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Vol. 9, Issue 7 (2020)

Evaluation of anxiolytic effect of hydro alcohol extract of stem bark from Cassia sieberiana in mice

Author(s):
Bakou Niangoran Fran├žois, BA Abdoulaye, Guiro Hamidou and Atayi E
Abstract:
Background: To study the anxiolytic activity of the hydro ethanolic extract of stem bark from Cassia sieberiana (CS). Methods: Male Swiss albino mice were used. Hydro ethanolic extract of stem bark from Cassia sieberiana (CS) was administered in the doses of 100, 200 and 400 mg/kg i.p. Hole board (HB), open field (OF), elevated plus maze (EPM) tests were used for determination of anxiolytic activity.
Results: The hydro ethanolic extract of stem bark from Cassia sieberiana (CS) significantly increased the number and duration of head poking in HB test. The extract also significantly increased the time spent and the number of entries in open arm in EPM. In OFT, the extract showed significant increase in number of rearing, assisted rearing and the squares crossed. Conclusions: In the present study, CS exhibited anxiolytic activity which might be attributed to its phytoconstituents like alkaloid, steroid and triterpenes. Since Cassia sieberiana (CS) is ubiquitous and abundantly grown, it could be a fairly economical therapeutic agent for management of anxiety disorders.
Pages: 294-297  |  488 Views  52 Downloads


The Pharma Innovation Journal
How to cite this article:
Bakou Niangoran François, BA Abdoulaye, Guiro Hamidou, Atayi E. Evaluation of anxiolytic effect of hydro alcohol extract of stem bark from Cassia sieberiana in mice. Pharma Innovation 2020;9(7):294-297.

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