Vol. 9, Issue 7 (2020)

Author(s):
Renu Singh, AK Srivastava, Neeraj Kumar Gangwar and Shyama N Prabhu

Abstract:
The present study was to investigate the propensity of Sodium fluoride to induce hepatotoxicity and oxidative stress and also to assess the ameliorative effect of vitamin E. For this purpose, a total of 24 rats were randomly divided into four groups: group I used as control and groups II, III and IV were orally treated with Sodium fluoride (8 mg/kg body weight), Vitamin E (100 mg/kg body weight) and Sodium fluoride plus Vitamin E, respectively for 45days. Results obtained showed that mean values of SOD, GSH and catalase revealed significant decrease while there was significant increase in LPO in liver homogenate in Sodium fluoride administration. Enzymatic activities of aminotransferases (AST and ALT) and phosphatase (ALP) in plasma were significantly increased due to Sodium fluoride administration. Further, light microscope investigation revealed that Sodium fluoride exposure induced histopathological alterations in the liver tissues. On the other hand, treatment with Vitamin E alleviated the harmful effect of Sodium fluoride in the combination group. The presence of Vitamin E could diminish the Sodium fluoride induced hepatotoxicity and oxidative stress in male wistar rats as indicated by the result of our study.