Vol. 9, Issue 5 (2020)

Author(s):
Ayan KR Kar, Pratik Samanta, Banhishikha Kar and Rana Majumdar

Abstract:
Microspheres are fundamentally free-flowing powders consisting of a biodegradable polymer matrix where an active therapeutic agent dispersed uniformly within the matrix system and the loaded drug released in a controlled manner over a long period. As a modern drug-captured delivery tool, controlled drug delivery system released the entrapped drugs at the target site in a controlled manner. The focus of the present investigation is to design a microsphere formulation based on the drug-polymer ratio. Other parameters related to the formulation kept constant. Dicyclomine hydrochloride loaded guar gum-based microsphere was accomplished by ionotropic gelation method and characterized by different process parameters like particle size, entrapment efficiency etc. The compatibility study of drug with formulation components was confirmed by differential scanning calorimetry and fourier transform infrared study. The particle size increased with enhancing the amount of guar gum. In vitro release profile was done using USP dissolution apparatus II in different pH media which was found to be a pH-sensitive profile after 12 h. The release kinetics was fitted with zero-order kinetics and case II transport system according to the Korsmeyer-Peppas model. The present study introduces an approach for the fabrication of microspheres for prolonged release of Dicyclomine hydrochloride and it can be used effectively as a drug targeting delivery tool with increased therapeutic efficacy.