Vol. 9, Issue 4 (2020)
Gross pathology in female wistar rats due to hexavalent chromium toxicity
Mylaram Jeevana Latha, M Lakshman, A Anand Kumar, A Gopal Reddy and D Pramod Kumar
An experiment was conducted for a period of four months by obtaining 120 female wistar rats to study the toxico pathological effects of hexavalent chromium. The experimental design consisted of six dietary groups, each group was divided into four replications containing five rats in each. These were fed with control (Group- I), Toxin (Group-II), Vitamin C control (Group –III), emblica officinalis control (Group-IV) and ameliorative groups (Groups V and VI). Rats were sacrificed at monthly interval on 30th, 60th, 90th day of experiment and its embryos. Tissue samples of liver, kidney, ovary, uterus, lungs, spleen, heart, fallopian tubes were collected for gross pathological studies. The results indicated a greater damage to internal organs when fed with toxic diets. These adverse effects were moderately ameliorated by Vitamin C and emblica officinalis. The group –III and Group – IV results were absolutely normal
How to cite this article:
Mylaram Jeevana Latha, M Lakshman, A Anand Kumar, A Gopal Reddy, D Pramod Kumar. Gross pathology in female wistar rats due to hexavalent chromium toxicity. Pharma Innovation 2020;9(4):04-06.