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Vol. 9, Issue 3 (2020)

Design, optimization, and validation of chemometrics assisted spectrophotometric methods for simultaneous determination of brexpiprazole and aripiprazole

Author(s):
Parth Patel and Rajashree Mashru
Abstract:
Four chemometrics methods were applied to simultaneous determination of Brexpiprazole and Aripiprazole in simulated mixture. Classical least-square (CLS), inverse least-square (ILS), principal component regression (PCR) and partial least-square (PLS) methods do not need any priori graphical treatment of the overlapping spectra of two drugs in a mixture. For all chemometrics calibration a concentration set of the random mixture consisting of the two drugs in methanol was prepared. The absorbance data in the UV spectra were measured for the 23 wavelength points (from 240 to 350 nm) in the spectral region 200-400 nm considering the intervals of Δλ=5nm. The calibration of the investigated methods involves only absorbance and concentration data matrices. The developed calibration were tested for the simulated mixtures consisting of two drugs and using MATLAB 2012b and unscrambler x software the chemometrics calculations were performed. In conclusion, it is claimed that these new chemometrics-assisted spectrophotometric methods are inexpensive, rapid, and simple and can be trustfully carried out in quality control laboratories.
Pages: 258-265  |  573 Views  128 Downloads


The Pharma Innovation Journal
How to cite this article:
Parth Patel, Rajashree Mashru. Design, optimization, and validation of chemometrics assisted spectrophotometric methods for simultaneous determination of brexpiprazole and aripiprazole. Pharma Innovation 2020;9(3):258-265.

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