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Vol. 9, Issue 3 (2020)

Development of hepatoprotective polyherbal formulation from methanolic extracts of stems of Berberis aristata, fruits of Piper longum and roots of Boerhaavia diffusa

Author(s):
Dr. RB Sharma and Rachna Verma
Abstract:
Liver plays a vital role in the metabolism of various exogenous and endogenous compounds. As a result of its, continuous involvement, is susceptible to toxic injuries caused by certain agents and any damage to hepatic cells disturb body metabolism. Indiscriminate use of systemic agents like tetracycline, paracetamol, anti-tubercular drugs, oral contraceptives of hormonal origin, chemicals used as food preservatives and agrochemicals are threatening the integrity of the liver. The present study is therefore undertaken to explore the effects of methanolic extracts of stem of Berberis aristata, roots of Boerhaavia diffusa and fruits of Piper longum. Development and evaluations of Hepatoprotective Polyherbal Formulation showing significant activity. The objective of present study is development of Hepatoprotective Polyherbal Formulation. Methanolic extracts of stem of Berberis aristata, roots of Boerhaavia diffusa and fruits of Piper longum were formulated for hepatoprotective formulation. Polyherbal formulation was prepared by dissolving extracts in 100ml purified water containing solubilizer, hydrotropic agent, suspending agent, 66.7%w/w sucrose and heated until complete dissolved with occasional shaking. Formulation F3 Formulated Polyherbal Formulation was evaluated for organoleptic characters (colour, odour and taste), density, viscosity, pH, specific gravity, turbidity and homogeneity. Evaluation parameters for formulations have shown good results within the specification of I.P. Polyherbal Formulation was formulated containing mixture of methanolic extracts of different experimental plants.
Acceleratory stability study has indicated that the formulation was stable, homogeneity was maintained and no turbidity was found for long time of storage was formulated containing mixture of methanolic extracts of different experimental plants.
Acceleratory stability study has indicated that the formulation was stable, homogeneity was maintained and no turbidity was found for long time of storage.
Pages: 21-25  |  182 Views  13 Downloads
How to cite this article:
Dr. RB Sharma, Rachna Verma. Development of hepatoprotective polyherbal formulation from methanolic extracts of stems of Berberis aristata, fruits of Piper longum and roots of Boerhaavia diffusa. Pharma Innovation 2020;9(3):21-25.
The Pharma Innovation Journal