Abstract: Livestock plays an important role in Indian rural economy and is a prime agricultural subsector. Endoparasites infections in domestic animals cause huge economical losses to the farmers. Nematodes like Strongyloides spp. are obligate gastrointestinal parasites of vertebrates. The larvated eggs of the Strongyloides spp. are expelled in the faeces of the host animals. The current study describes the clinical signs, diagnosis via microscopic faecal examination and medicinal management of Strogyloides spp. infection in Murrah calves. The infected calves were successfully treated with Piperazine and Levamisole.