Ameliorative effect of Tribulus terrestris on haematological parameters against acephate induced subacute toxicity in Wistar rats
Payal Rathod, Hajare SW, Sapna Jamgade, RS Ingole, MV Ingawale, Pawar Pooja and SP Waghmare
In the present research work ameliorative effect of Tribulus terrestris on subacute acephate induced toxicity was studied from general performance and evaluation of haematological parameters in male Wistar rats”. Thirty male Wistar rats were divided equally into five groups, group I served as a control and treated with normal saline while group II treated with acephate @ 75 mg/kg bw p.o. once daily for 15 days and acephate was withdrawn for next 15 days. Group III treated with acephate @ 75 mg/kg bw for 30 days, group IV treated initial 15 days with acephate @ 75 mg/kg bw and Tribulus terrestris @ 100 mg/kg bw for rest of 15 days p.o. once daily and group V treated with acephate @ 75 mg/kg bw + Tribulus terrestris @ 100 mg/kg bw from day 1-30. From the results of study significant reduction (P≤0.05) was observed in mean body weight of rats from group II and III treated with acephate. However, combination groups (acephate + Tribulus terrestris) IV and V showed least decrease in mean body weight as compared to acephate alone treated groups. Rats treated with acephate alone showed significant (P≤0.05) decrease in Hb, PCV, TEC and TLC values. Tribulus terrestris treated groups IV and V showed least change in Hb, PCV, TEC and TLC values. In differential leucocytes count, the mean neutrophil count was found significantly (P≤0.05) higher in group II and III as compared to control. However, group IV and V showed least alteration in neutrophil count. The mean lymphocyte and monocyte count in group II and group III treated rats decreased significantly (P≤0.05) as compared to control however, group IV and V rats indicated non-significant differences as comparable to control group. In conclusion, acephate produces signs of deleterious effect on haematological parameters which were ameliorated by treatment with hydroethanolic fruit extract of Tribulus terrestris.
How to cite this article:
Payal Rathod, Hajare SW, Sapna Jamgade, RS Ingole, MV Ingawale, Pawar Pooja, SP Waghmare. Ameliorative effect of Tribulus terrestris on haematological parameters against acephate induced subacute toxicity in Wistar rats. Pharma Innovation 2020;9(2):23-26.