Vol. 9, Issue 10 (2020)

Materials and Methods: Forty five (45) patients of newly diagnosed type II diabetics with retinopathy and twenty (20) age and sex matched healthy non-diabetic & normotensive individuals of age between 20-65 were selected as the controls. In all cases and controls Fundoscopy was examined by ophthalmologist and severity of retinopathy was graded according to International clinical Diabetic retinopathy Disease severity scale. Complete blood counts (CBC), renal function test (RFT), liver function test (LFT), plasma glucose fasting and postprandial, HbA1c,urine routine/microscopy, 12 lead ECG were done all the cases and controls. Serum VEGF and Apo-A1 level was estimated using ELISA kit. The statistical analysis was done using SPSS for Windows version 16.0 software. For comparing two group of mean Students ‘t’ test and Mann-Whitney U test was used to compare VEGF and APO-A1 in the groups. The p value was considered as statistically significant when it is <0.05.

Conclusion: In our study we have shown that serum VEGF level represents very well with the severity of retinopathy. It can be a potential tool for diabetic retinopathy early detection and probable severity prediction. Serum Apo-A1 is significantly lower in more severe retinopathy group, suggesting its protective role. In our region data regarding these two marker are scanty and these results should be validated in larger study population.