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Vol. 8, Issue 9 (2019)

Effect of zidovudine on fetal length & fetal weight of developing mice

Author(s):
Amit Kumar Nayak, Anand Mishra, Krishna Pandey, Amrita Singh and Kapil Kumar Malviya
Abstract:
Introduction: Zidovudine was the first antiretroviral agent to demonstrate clinical efficacy in patients infected with HIV. Its currently widely used as a part of highly active antiretroviral therapy. The current study is done to see the effect of zidovudine on fetal length & fetal weight of swiss albino mice.
Material & method: Zidovudine was given to mice in doses of 50,100 & 150 mg/kgbw. Length & weight of fetuses were measured.
Result: Dose dependent decrease in fetal length & fetal weight was observed.
Conclusion: In this study we concluded that zidovudine is teratogenic to developing mice & should be cautiously used in clinical cases.
Pages: 423-425  |  230 Views  35 Downloads


The Pharma Innovation Journal
How to cite this article:
Amit Kumar Nayak, Anand Mishra, Krishna Pandey, Amrita Singh, Kapil Kumar Malviya. Effect of zidovudine on fetal length & fetal weight of developing mice. Pharma Innovation 2019;8(9):423-425.

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