Endothelial dysfunction complications and current status
Arun Kumar and Mustafa Raza Ansari
In past, endothelium was thought to be only a mechanical barrier. In present time, endothelium is known to be a tissue regulating vascular tone, cell growth and the interaction between leukocytes, thrombocytes and various blood vessel wall. It also synthesizes growth factors and thrombo-regulatory molecules and responds to physical and chemical stimuli. Even though endothelial dysfunction is a complex term in itself. It is generally used for the incompetent endothelium-dependent vasodilatation, the term also covers the abnormalities between endothelium and thrombocytes, leukocytes and other regulatory protein molecules. Fit and healthy endothelium is considered very essential for cardiovascular control. Thus, endothelium layers play a dynamic role in pathogenesis of many diseases and cardiovascular problems such as congestive heart failure, atherosclerosis, systemic and pulmonary hypertension, cardiomyopathies and vasculitis. The main aim of this article is to enlighten the endothelial dysfunction and the circulating molecules of endothelial cells as they become potential targets of therapeutic approach for hypertension and other cardiovascular diseases. This article also reviews the role and importance of endothelial dysfunction in hypertension by addressing the nature of the endothelial function, different mechanisms of the endothelial dysfunction and its relationship with the disease. The key associations between hypertension and endothelial dysfunction are vitally very important for future studies to allow new and novel interventions to be designed and released.
How to cite this article:
Arun Kumar, Mustafa Raza Ansari. Endothelial dysfunction complications and current status. Pharma Innovation 2019;8(9):25-33.