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Vol. 8, Issue 8 (2019)

Pharmacological screening and effect of Elettaria cardamomum extract on depression-like behaviour in rat model

Author(s):
Mansi Singh and Sanjesh Kumar
Abstract:
Depression is a heterogenous mood disorder that has been classified and treated in variety of ways. Although a number of synthetic drugs are being used as standard treatment for clinically depressed patient, they have adverse effects that can compromise the therapeutic treatment. Thus, it is worthwhile to look for antidepressant from plants with proven advantage and favorable benefit to risk ratio. A number of medicinal plants and medicine derived from these plants have shown antidepressant properties by virtue of combined effect of their medicinal constituents. The causes of depression are decreased brain levels of monoamines like noradrenaline, dopamine and serotonin. Therefore, drugs restoring the reduced levels of these monoamines in the brain either by inhibiting monoamine oxidase or by inhibiting reuptake of these neurotransmitters might be fruitful in the treatment of depression. The present review is focused on the medicinal plants to investigate the possible effect of Elettaria cardamomum seed extract on depression-like behavior using experimental model in laboratory animals.
The present study was undertaken to assess the antidepressant effect of crude methanolic extract of seed of Elettaria cardamom at doses 200mg/kg and 400mg/kg using forced induced swimming test (FST imipramine (20mg/kg, body weight) was used as standard. Significant dose dependent decline in immobility time was observed in doses in FST of Elettaria cardamom extract exhibited effectual results.
Pages: 401-404  |  354 Views  112 Downloads


The Pharma Innovation Journal
How to cite this article:
Mansi Singh, Sanjesh Kumar. Pharmacological screening and effect of <em>Elettaria cardamomum</em> extract on depression-like behaviour in rat model. Pharma Innovation 2019;8(8):401-404.

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