Vol. 8, Issue 8 (2019)

Author(s):
Krishna Jadav and Rajashree Mashru

Abstract:
The present research work describes simple, sensitive, accurate, rapid, precise and economic UV Spectrophotometric, Chemometric assisted and RP-HPLC methods for simultaneous estimation of Aripiprazole and Lamotrigine in bulk and synthetic mixture. UV Spectrophotometric methods applied are: (i) Absorption Correction Method (ii) First Derivative Zero Crossing Point Method (iii) Chemometrics assisted UV spectrophotometric methods. The RP-HPLC method applied by QbD approach and Force Degradation study are carried out by RP-HPLC Method. The Proposed methods have been validated as per ICH guideline and successfully applied to the simultaneous estimation of Aripiprazole and Lamotrigine in their Laboratory Synthetic Mixture.